The Products of Bone Resorption and Their Roles in Metabolism: Lessons from the Study of Burns

Surprisingly little is known about the factors released from bone during resorption and metabolic roles they play. This paper describes what we have learned bone, mainly through study of burn injuries, play in post-burn metabolism. From these studies, know that calcium, phosphorus, magnesium, along with transforming growth factor (TGF)-?, are following resorption. Additionally, studies mice Karsenty’s laboratory indicated undercarboxylated osteocalcin also Questions arising observations discussed as well a variety potential conditions which release could significant role pathophysiology conditions. Therapeutic implications understanding yet other unidentified raised. While much remains unknown, has been observed provides glimpse importance this area study.